Post date: Application deadline:
03/06/2019
Job Description:

For full PhD studies, our lab is looking for students with a background in physiology, molecular biology or immunology to investigate the exciting link between the immune system and cardiovascular disease.

Targeting S1P signaling as novel strategy to treating hypertension and associated target organ damage

Hypertension is the leading cause of disease burden in the developed world and a major modifiable risk factor for the development of several degenerative conditions in target organs including the brain. The immune system not only contributes to development and progression of hypertension but also unfavorably affects target organs, including the brain.

Our laboratory recently described a fundamental contribution of the bioactive phospholipid sphingosine-1-phosphate (S1P) to the pathogenesis of experimental hypertension, whereby S1P plasma levels serve as chemotactic signal to attract activated T-lymphocytes from secondary lymphoid tissue (e.g., spleen and lymph nodes) to the circulating blood. 

We aim to explore the involvement of the S1P signaling axis in immune responses during hypertension, and how its modulation might be able to reduce blood pressure levels. Furthermore, we aim to expand upon findings that define S1P as an important chemotactic substance for T-cell trafficking to the hypertensive brain.

 

Requirements:

  • Graduate or master's degree from medical, biomedical, chemistry / biology, bioengineering or other relevant natural science or engineering education. 
  • Documented experience of laboratory work such as cell culture, animal work, vascular biology, cell and molecular biology techniques and immunological approaches.
  • Ability to work independently as assessed from undergraduate and masters thesis experiments or discussion of science during the interview 
  • Good oral and written proficiency in English 
  • Good written and oral communication skills 
  • Ability to work well in a team

 

Literature:

A Meissner, F Miro, F Jimenez-Altayo, A Jurado, E Vila and A Planas. Sphingosine-1-phosphate signaling a key player in the pathogenesis of Angiotensin II-induced hypertension. Cardiovasc Res. 2017 Jan 12. doi: 10.1093/cvr/cvw256.

Nicholas Don-Doncow, Lotte Vanherle, Yun Zhang & Anja Meissner. T-cell accumulation in the hypertensive brain: a role for sphingosine-1-phosphate-mediated chemotaxis. Int J Mol Sci. 2019 Jan 28;20(3). doi: 10.3390/ijms20030537.

Nicholas Don-Doncow, Yun Zhang, Hana Matuskova and Anja Meissner. The emerging alliance of sphingosine-1-phosphate signaling and immune cells: from basic mechanisms to implications in hypertension. Br J Pharmacol. 2018 Jun 1. doi: 10.1111/bph.14381.

 

Contact:

Anja Meissner (anja.meissner@med.lu.se)

Lund University and
Wallenberg Centre for Molecular Medicine (WCMM)
BMC D12, Klinikgatan 32
221 84 Lund, SWEDEN